core
type: Ontology
comment: Properties and classes used for protein annotation.

name
type: AnnotationProperty
type: ObjectProperty
sub property of: label
type: DatatypeProperty
data property range: string
data property domain: Class
  union of: Book Citation
  union of: Journal Citation
data property domain: Class
  union of: Book Citation
  union of: Journal Citation

common name
type: AnnotationProperty
type: DatatypeProperty
type: FunctionalProperty
domain: Taxon
sub property of: name
range: string

locus name
type: AnnotationProperty
type: DatatypeProperty
domain: Gene
sub property of: name
range: string

mnemonic
type: AnnotationProperty
type: DatatypeProperty
comment: A easy to remember identifier for a UniProtKB entry, but it is not a stable identifier and should not be used by programs to identify entries.
sub property of: name
range: string
domain: Class
  union of: Cluster
  union of: Protein
  union of: Sequence
domain: Class
  union of: Cluster
  union of: Protein
  union of: Sequence

alternativeName
type: ObjectProperty
comment: A synonym of the recommended name.
range: Structured Name
sub property of: structuredName
domain: Class
  union of: Part
  union of: Protein
domain: Class
  union of: Part
  union of: Protein

annotation
type: ObjectProperty
comment: Attaches an annotation to a resource.
range: Annotation
domain: Protein

based on
type: ObjectProperty
type: FunctionalProperty
comment: The sequence on which the description of a modified sequence is based.
domain: Modified Sequence
range: Simple Sequence

cellularComponent
type: ObjectProperty
range: Cellular Component
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1

citation
type: ObjectProperty
comment: A publication from which data was extracted, or which contains additional information.
range: Citation
domain: Class
  union of: Cellular Component
  union of: Database
  union of: External Sequence
  union of: Nucleotide Resource
  union of: Orientation
  union of: Protein
  union of: Topology
domain: Class
  union of: Cellular Component
  union of: Database
  union of: External Sequence
  union of: Nucleotide Resource
  union of: Orientation
  union of: Protein
  union of: Topology

classified with
type: ObjectProperty
comment: A concept that classifies this resource.
range: Concept
domain: Protein

component
type: ObjectProperty
comment: A component of a protein.
range: Part
domain: Protein
sub property of: part

domain
type: ObjectProperty
comment: A domain of a protein.
range: Part
domain: Protein
sub property of: part

encoded by
type: ObjectProperty
comment: The gene by which a protein is encoded.
range: Gene
domain: Protein

encoded in
type: ObjectProperty
comment: The subcellular location where a protein is encoded.
domain: Protein
range: Subcellular Location

enzyme
type: ObjectProperty
comment: The catalytic activity associated with a protein. or part of a protein.
range: Enzyme
domain: Class
  union of: Part
  union of: Protein
domain: Class
  union of: Part
  union of: Protein

erratum
type: ObjectProperty
comment: An erratum for a publication.
range: Published Citation
domain: Published Citation

erratum for
type: ObjectProperty
comment: The publication which an erratum refers to.
domain: Published Citation
range: Published Citation
inverse of: erratum

locatedIn
type: ObjectProperty
domain: Subcellular Location
range: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1
range: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1

located on
type: ObjectProperty
comment: The molecule a this resource is located on.
range: Molecule
domain: Nucleotide Resource

member
type: ObjectProperty
comment: One of several similar resources.
domain: Cluster
range: Sequence

member of
type: ObjectProperty
range: Cluster
domain: Sequence
inverse of: member

method
type: ObjectProperty
comment: The experimental method that was used.
range: Method
domain: Class
  union of: Mass
  union of: Structure Resource
domain: Class
  union of: Mass
  union of: Structure Resource

modification
type: ObjectProperty
comment: A modification of a sequence.
range: Splice Variant
domain: Modified Sequence

organism
type: ObjectProperty
comment: The organism in which a protein occurs.
range: Taxon
domain: Class
  union of: Protein
  union of: Sequence
domain: Class
  union of: Protein
  union of: Sequence

orientation
type: ObjectProperty
range: Orientation
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1

participant
type: ObjectProperty
comment: A protein that participates in a protein-protein interaction.
domain: Interaction
range: Participant

range
type: ObjectProperty
comment: A range of amino acids.
range: Range
domain: Sequence Annotation

rank
type: ObjectProperty
type: FunctionalProperty
comment: The rank of a taxon.
range: Rank
domain: Taxon

recommendedName
type: ObjectProperty
comment: The name recommended by the UniProt consortium.
range: Structured Name
sub property of: structuredName
domain: Class
  union of: Part
  union of: Protein
domain: Class
  union of: Part
  union of: Protein

replaced by
type: ObjectProperty
comment: A resource that replaces this resource.
inverse of: replaces
range: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon
domain: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon
range: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon
domain: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon

replaces
type: ObjectProperty
comment: A resource that is replaced by this resource.
domain: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon
range: Class
  intersection of: Obsolete
  intersection of: Class
    union of: Enzyme
    union of: Protein
    union of: Taxon
domain: Class
  union of: Enzyme
  union of: Protein
  union of: Taxon
range: Class
  intersection of: Obsolete
  intersection of: Class
    union of: Enzyme
    union of: Protein
    union of: Taxon

sequence
type: ObjectProperty
comment: An amino acid sequence.
range: Sequence
domain: Class
  union of: Annotation
  union of: Protein
  union of: Resource
domain: Class
  union of: Annotation
  union of: Protein
  union of: Resource

sequence for
type: ObjectProperty
comment: A resource that describes this sequence.
domain: Sequence
inverse of: sequence
range: Class
  union of: Annotation
  union of: Protein
  union of: Resource
range: Class
  union of: Annotation
  union of: Protein
  union of: Resource

status
type: ObjectProperty
type: FunctionalProperty
comment: The reliability of a statement.
range: Status

submittedName
type: ObjectProperty
comment: A name provided by the submitter of the underlying nucleotide sequence.
range: Structured Name
sub property of: structuredName
domain: Class
  union of: Part
  union of: Protein
domain: Class
  union of: Part
  union of: Protein

topology
type: ObjectProperty
range: Topology
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1
domain: Class
  intersection of: Restriction
    on property: cellularComponent
    on class: Cellular Component
    qualified cardinality: 1
  intersection of: Restriction
    on property: orientation
    on class: Orientation
    max qualified cardinality: 1
  intersection of: Restriction
    on property: topology
    on class: Topology
    max qualified cardinality: 1

abstract
type: DatatypeProperty
type: FunctionalProperty
comment: True if the class does not have any direct instances.
domain: Database
range: boolean

catalytic activity
type: DatatypeProperty
comment: The description of a catalytic activity.
domain: Enzyme
range: string

alias
type: DatatypeProperty
comment: An alternative name used in the flat text format.
range: string

allergenName
type: DatatypeProperty
comment: See http://www.expasy.org/cgi-bin/lists?allergen.txt
sub property of: structuredNameType

atypical
type: DatatypeProperty
type: FunctionalProperty
comment: True if the protein is divergent in sequence or has mutated functional sites.
domain: Family Membership Statement
range: boolean

author
type: DatatypeProperty
comment: The author of a publication.
domain: Citation
range: string

begin
type: DatatypeProperty
type: FunctionalProperty
comment: The first position of a range.
range: int
domain: Class
  union of: Range
  union of: Sequence
domain: Class
  union of: Range
  union of: Sequence

biotechName
type: DatatypeProperty
comment: A name used in a biotechnological context.
sub property of: structuredNameType

cdAntigenName
type: DatatypeProperty
comment: A name from the Human Cell Differentiation Molecules (HCDM) nomenclature.
sub property of: structuredNameType

certain
type: DatatypeProperty
type: FunctionalProperty
comment: False if there is any uncertainty about a statement.
range: boolean
domain: Class
  union of: Absorption
  union of: Domain Assignment Statement
  union of: Endpoint Statement
domain: Class
  union of: Absorption
  union of: Domain Assignment Statement
  union of: Endpoint Statement

chain
type: DatatypeProperty
comment: Maps a series of symbols representing chains of a protein to a range of amino acids.
domain: Structure Mapping Statement
range: string

checksum
type: DatatypeProperty
comment: An caclulated value that is used to detect if there are errors in the sequence as shown due to among others IO errors. Both the crc64 and md5sum have collisions in UniProt data and cannot be used as unique keys.

cofactor
type: DatatypeProperty
comment: A cofactor required for a catalytic activity.
domain: Enzyme
range: string

created
type: DatatypeProperty
type: FunctionalProperty
comment: The date a resource was created.
range: date
domain: Class
  union of: Protein
  union of: Resource
  union of: Sequence
domain: Class
  union of: Protein
  union of: Resource
  union of: Sequence

domains
type: DatatypeProperty
type: FunctionalProperty
comment: The number of domains in a protein that correspond to a family. This is almost always 1, but may be 2 if two identical domains are fused.
domain: Family Membership Statement
range: int

ecName
type: DatatypeProperty
comment: The ecName is the enzyme classification associated with a structured name of the protein. Proteins are often named after their enzymatic activity but can have more than one activity leading to multiple names.
sub property of: structuredNameType

editor
type: DatatypeProperty
comment: The editor of a publication.
domain: Book Citation
range: string

end
type: DatatypeProperty
type: FunctionalProperty
comment: The last position of a range.
range: int
domain: Class
  union of: Range
  union of: Sequence
domain: Class
  union of: Range
  union of: Sequence

false negative
type: DatatypeProperty
type: FunctionalProperty
comment: True if a statement is true even though it was not predicted.
domain: Domain Assignment Statement
range: boolean

fragment
type: DatatypeProperty
comment: Indicates if a sequence is complete or consists of one or more fragments.
domain: Simple Sequence
range: DataRange
  one of: multiple
  one of: single
range: DataRange
  one of: multiple
  one of: single

frameshift
type: DatatypeProperty
comment: True if a sequence modification causes a frameshift.
domain: RNA Editing
range: boolean

fullName
type: DatatypeProperty
comment: The full name.
sub property of: structuredNameType

fused
type: DatatypeProperty
type: FunctionalProperty
comment: True if the rule on which the membership of a protein to a family is based does not cover the entire protein.
domain: Family Membership Statement
range: boolean

group
type: DatatypeProperty
comment: The group or consortium that authored a publication.
domain: Citation
sub property of: author
range: string

hits
type: DatatypeProperty
type: FunctionalProperty
comment: The number of hits found in a sequence.
domain: Domain Assignment Statement
range: int

identity
type: DatatypeProperty
type: FunctionalProperty
comment: The level of sequence identity in a cluster.
domain: Cluster
range: DataRange
  one of: 0.5
  one of: 0.9
  one of: 1.0
range: DataRange
  one of: 0.5
  one of: 0.9
  one of: 1.0

implicit
type: DatatypeProperty
type: FunctionalProperty
comment: True if existance of this resource can be inferred.
domain: Database
range: boolean

institution
type: DatatypeProperty
comment: The institution at which a thesis was written.
domain: Thesis Citation
range: string

internationalNonproprietaryName
type: DatatypeProperty
comment: The international nonproprietary name: A generic name for a pharmaceutical substance or active pharmaceutical ingredient that is globally recognized and is a public property.
sub property of: structuredNameType

limit
type: DatatypeProperty
type: FunctionalProperty
comment: True if the range does not extend beyond the specified endpoint.
domain: Endpoint Statement
range: boolean

mass
type: DatatypeProperty
type: FunctionalProperty
comment: The mass of a sequence in Daltons.
domain: Simple Sequence
range: int

maximum
type: DatatypeProperty
type: FunctionalProperty
comment: A maximum value.
domain: Absorption
range: float

measured activity
type: DatatypeProperty
comment: The maximum velocity, Vmax.
domain: Kinetics
range: string

measured affinity
type: DatatypeProperty
comment: The Michaelis-Menten constant, Km.
domain: Kinetics
range: string

measured error
type: DatatypeProperty
type: FunctionalProperty
comment: The magnitude of the error of a value that was measured.
domain: Mass
range: float

measured value
type: DatatypeProperty
type: FunctionalProperty
comment: A value that was measured.
domain: Mass
range: float

modified
type: DatatypeProperty
type: FunctionalProperty
comment: The date a resource was last modified.
range: date
domain: Class
  union of: Cluster
  union of: Protein
  union of: Sequence
domain: Class
  union of: Cluster
  union of: Protein
  union of: Sequence

obsolete
type: DatatypeProperty
type: FunctionalProperty
comment: True if this resource has been replaced or deleted.
range: boolean
domain: Class
  union of: Protein
  union of: Taxon
domain: Class
  union of: Protein
  union of: Taxon

oldMnemonic
type: DatatypeProperty
comment: A mnemonic that is no longer in use for this entry.
domain: Protein
sub property of: name
range: string

ORF name
type: DatatypeProperty
domain: Gene
sub property of: name
range: string

other name
type: DatatypeProperty
domain: Taxon
sub property of: name
range: string

pages
type: DatatypeProperty
type: FunctionalProperty
comment: The first and last page for a chapter or article.
range: string
domain: Class
  union of: Book Citation
  union of: Journal Citation
domain: Class
  union of: Book Citation
  union of: Journal Citation

part of lineage
type: DatatypeProperty
type: FunctionalProperty
comment: True for taxa that can appear as part of an organism's lineage.
domain: Taxon
range: boolean

partial
type: DatatypeProperty
type: FunctionalProperty
comment: True if the pattern or profile on which the domain assignment is based did not detect the sequence because the sequence is not complete and lacks the region on which the pattern or profile is based.
domain: Domain Assignment Statement
range: boolean

pattern
type: DatatypeProperty
type: FunctionalProperty
comment: A URL pattern, used to generate links by substituting an identifier.
domain: Database
range: string

place
type: DatatypeProperty
type: FunctionalProperty
comment: The place where a publication was published. This usually includes a country name.
range: string
domain: Class
  union of: Book Citation
  union of: Thesis Citation
domain: Class
  union of: Book Citation
  union of: Thesis Citation

position
type: DatatypeProperty
comment: A position on a sequence.
domain: RNA Editing
range: int

publisher
type: DatatypeProperty
comment: The publisher of a book.
domain: Book Citation
range: string

resolution
type: DatatypeProperty
type: FunctionalProperty
comment: The resolution of an experiment, in Angstrom.
domain: Structure Resource
range: float

reviewed
type: DatatypeProperty
type: FunctionalProperty
comment: Indicates whether a resource has been reviewed by a curator.
range: boolean
domain: Class
  union of: Protein
  union of: Taxon
domain: Class
  union of: Protein
  union of: Taxon

scientific name
type: DatatypeProperty
type: FunctionalProperty
domain: Taxon
sub property of: name
range: string

scope
type: DatatypeProperty
comment: The extent of the work carried out by the authors of a publication.
domain: Citation Statement
range: string

shortName
type: DatatypeProperty
comment: An abbreviation of the full name or an acronym.
sub property of: structuredNameType

structuredNameType
type: DatatypeProperty
comment: All names of the protein, from commonly used to obsolete, to used in the literature..
domain: Structured Name
range: string

submittedTo
type: DatatypeProperty
comment: The database a resource was submitted to.
domain: Submission Citation

substitution
type: DatatypeProperty
comment: A replacement sequence.
range: string
domain: Class
  union of: Mutagenesis Site
  union of: Sequence Variant
  union of: Sequence Conflict
domain: Class
  union of: Mutagenesis Site
  union of: Sequence Variant
  union of: Sequence Conflict

title
type: DatatypeProperty
type: FunctionalProperty
comment: The title of a publication.
domain: Citation
range: string

volume
type: DatatypeProperty
type: FunctionalProperty
comment: The volume a publication is part of.
domain: Class
  union of: Book Citation
  union of: Journal Citation
domain: Class
  union of: Book Citation
  union of: Journal Citation

Absorption
type: Class
subclass of: Biophysicochemical Property
comment: Indicates the wavelength in nm at which photoreactive proteins such as opsins and DNA photolyases show maximal absorption.

Active Site
type: Class
subclass of: Site
comment: Amino acid(s) involved in the activity of an enzyme.

Allergen
type: Class
subclass of: Annotation
comment: Information relevant to allergenic proteins.

Alternative Initiation
type: Class
subclass of: Alternative Products

Alternative Products
type: Class
subclass of: Annotation
comment: Description of the existence of related protein sequences produced by alternative splicing of the same gene or by the use of alternative initiation codons.

Alternative Promoter Usage
type: Class
subclass of: Alternative Products

Splice Variant
type: Class
subclass of: Natural Variation
comment: Description of sequence variants produced by alternative splicing.

Alternative Splicing
type: Class
subclass of: Alternative Products

Annotation
type: Class
comment: Description of a resource on a specific topic.

Attribution
type: Class
comment: Entity used to attach evidence or provenance to a rdf statement via reification.

Strand
type: Class
subclass of: Secondary Structure
comment: Beta strand regions within the experimentally determined protein structure

Binding Site
type: Class
subclass of: Site
comment: Binding site for any chemical group (co-enzyme, prosthetic group, etc.).

Biophysicochemical Property
type: Class
subclass of: Annotation
comment: Biophysical and physicochemical data such as pH dependence, temperature dependence, kinetic parameters, redox potentials, and maximal absorption.

Biotechnology
type: Class
subclass of: Annotation
comment: Description of the use of a specific protein in a biotechnological process.

Book Citation
type: Class
subclass of: Published Citation
subclass of: Restriction
  on property: name
  cardinality: 1
comment: A chapter from a book.
subclass of: Restriction
  on property: name
  cardinality: 1

Calcium Binding
type: Class
subclass of: Region
comment: Extent of a calcium-binding region.

Catalytic Activity
type: Class
subclass of: Annotation
comment: Description of the reactions catalyzed by an enzyme.

Caution
type: Class
subclass of: Annotation
comment: Warning about possible errors and/or grounds for confusion.

Cellular Component
type: Class
subclass of: Subcellular Location

Chain
type: Class
subclass of: Molecule Processing
comment: Extent of a polypeptide chain in the mature protein.

Citation
type: Class
subclass of: Class
  union of: Restriction
    on property: date
    some values from: date
  union of: Restriction
    on property: date
    some values from: gYear
  union of: Restriction
    on property: date
    some values from: gYearMonth
disjoint with: Protein
disjoint with: Range
disjoint with: Sequence
comment: Description of a publication from which data was obtained.
subclass of: Class
  union of: Restriction
    on property: date
    some values from: date
  union of: Restriction
    on property: date
    some values from: gYear
  union of: Restriction
    on property: date
    some values from: gYearMonth

Citation Statement
type: Class
subclass of: Statement
subclass of: Restriction
  on property: context
  all values from: Class
    union of: Strain
    union of: Tissue
    union of: Transposon
comment: The relationship between a resource and a citation.
subclass of: Restriction
  on property: context
  all values from: Class
    union of: Strain
    union of: Tissue
    union of: Transposon

Cluster
type: Class
subclass of: Thing
subclass of: Restriction
  on property: member
  all values from: Sequence
disjoint with: Protein
disjoint with: Sequence
comment: Cluster of proteins with similar sequences.
subclass of: Restriction
  on property: member
  all values from: Sequence

Cofactor
type: Class
subclass of: Annotation
comment: Description of an enzyme cofactor.

Coiled-Coil
type: Class
subclass of: Region
comment: Extent of a coiled-coil region.

Compositionally Biased Region
type: Class
subclass of: Region
comment: Extent of a compositionally biased region.

Concept
type: Class
subclass of: Class
subclass of: Restriction
  on property: replaces
  all values from: Concept
comment: A concept used to classify resources.
subclass of: Restriction
  on property: replaces
  all values from: Concept

Crosslink
type: Class
subclass of: Modification
comment: Posttranslationally formed amino acid bonds.

Database
type: Class
subclass of: Class
comment: Metadata for a life science database.

Developmental Stage
type: Class
subclass of: Annotation
comment: Description of the developmentally-specific expression of a protein.

Disease
type: Class
subclass of: Annotation
comment: Description of the diseases associated with a deficiency of a protein.

Disruption Phenotype
type: Class
subclass of: Annotation

Disulfide Bond
type: Class
subclass of: Modification
comment: Describes residues which are linked by an intra-chain disulfide bond. If the endpoints are identical, the disulfide bond is an interchain one.

Domain
type: Class
subclass of: Annotation
comment: Description of the domain structure of a protein.

Domain Assignment Statement
type: Class
subclass of: Statement
comment: The relationship between a protein and a protein domain.

Domain Extent
type: Class
subclass of: Region
comment: Extent of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.

Electronic Citation
type: Class
subclass of: Published Citation
subclass of: Restriction
  on property: name
  cardinality: 1
comment: An electronic publication.
subclass of: Restriction
  on property: name
  cardinality: 1

Endpoint Statement
type: Class
subclass of: Statement
comment: Metadata for an endpoint of a range on a sequence.

Enzyme
type: Class
subclass of: Class
subclass of: Restriction
  on property: replaced by
  all values from: Enzyme
subclass of: Restriction
  on property: replaces
  all values from: Enzyme
comment: A specific catalytic activity, defined by the Enzyme Commission of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB).
subclass of: Restriction
  on property: replaced by
  all values from: Enzyme
subclass of: Restriction
  on property: replaces
  all values from: Enzyme

Enzyme Regulation
type: Class
subclass of: Annotation
comment: Description of an enzyme regulatory mechanism.

Erroneous Gene Model Prediction
type: Class
subclass of: Sequence Caution

Erroneous Initiation
type: Class
subclass of: Sequence Caution

Erroneous Termination
type: Class
subclass of: Sequence Caution

Erroneous Translation
type: Class
subclass of: Sequence Caution

Experimental Information
type: Class
subclass of: Sequence Annotation

External Sequence
type: Class
subclass of: Known Sequence
comment: The protein described in the linked record is an alternative splice form of the same gene product as described in this record. The function between the two isoforms is highly divergent.

Family Membership Statement
type: Class
subclass of: Statement
comment: The relationship between a protein and a protein family.

Frameshift
type: Class
subclass of: Sequence Caution

Function
type: Class
subclass of: Annotation
comment: General description of the functions of a protein.

Gene
type: Class
subclass of: Thing
subclass of: Concept
subclass of: Restriction
  on property: prefLabel
  on class: Gene
  qualified cardinality: 1
subclass of: Restriction
  on property: prefLabel
  on class: Gene
  qualified cardinality: 1

Genomic DNA
type: Class
subclass of: DNA

Genomic RNA
type: Class
subclass of: RNA

Glycosylation Site
type: Class
subclass of: Modification
comment: Describes the occurrence of the attachment of a glycan (mono- or polysaccharide) to a residue of a protein.

Helix
type: Class
subclass of: Secondary Structure
comment: Helical regions within the experimentally determined protein structure

Induction
type: Class
subclass of: Annotation
comment: Description of the compounds or conditions that stimulate the synthesis of a protein.

Initiator Methionine
type: Class
subclass of: Molecule Processing
comment: Indicates that the initiator methionine has been cleaved off and is not shown in the sequence.

Interaction
type: Class
comment: Description of a protein-protein interaction.

INTRAMEM
type: Class
subclass of: Region
comment: Extent of a region located in a membrane without crossing it

Journal Citation
type: Class
subclass of: Published Citation
subclass of: Restriction
  on property: name
  cardinality: 1
comment: An article published in a journal.
subclass of: Restriction
  on property: name
  cardinality: 1

Kinetics
type: Class
subclass of: Biophysicochemical Property
comment: Mentions the Michaelis-Menten constant (KM) and maximal velocity (Vmax) of enzymes.

Known Sequence
type: Class
subclass of: Sequence

Lipid Binding
type: Class
subclass of: Modification
comment: Covalent binding of a lipid moiety.

mRNA
type: Class
subclass of: RNA

Mass Measurement
type: Class
subclass of: Method
comment: An experimental method for measuring the mass of a molecule.

Mass
type: Class
subclass of: Experimental Information
subclass of: Restriction
  on property: method
  all values from: Mass Measurement
subclass of: Restriction
  on property: method
  max cardinality: 1
comment: Indicates the mass of a sequence determined by mass spectrometry.
subclass of: Restriction
  on property: method
  all values from: Mass Measurement
subclass of: Restriction
  on property: method
  max cardinality: 1

Metal Ion Binding Site
type: Class
subclass of: Site
comment: Binding site for a metal ion.

Method
type: Class
comment: An experimental method.

Modification
type: Class
subclass of: Sequence Annotation
comment: Describes amino acid modifications, post pre- and post-translational.

Modified Residue
type: Class
subclass of: Modification
comment: Posttranslational modification of a residue.

Modified Sequence
type: Class
subclass of: Known Sequence
subclass of: Restriction
  on property: based on
  all values from: Simple Sequence
subclass of: Restriction
  on property: modification
  all values from: Splice Variant
subclass of: Restriction
  on property: based on
  all values from: Simple Sequence
subclass of: Restriction
  on property: modification
  all values from: Splice Variant

Molecule
type: Class
comment: A biological molecule.

Molecule Processing
type: Class
subclass of: Sequence Annotation

Motif
type: Class
subclass of: Region
comment: Short (<=20 amino acids) sequence motif of biological interest.

Mutagenesis Site
type: Class
subclass of: Experimental Information
comment: Site which has been experimentally altered.

Nucleotide Phosphate Binding
type: Class
subclass of: Region
comment: Extent of a nucleotide phosphate-binding region.

Sequence Variant
type: Class
subclass of: Natural Variation
comment: Authors report that sequence variants exist.

Natural Variation
type: Class
subclass of: Sequence Annotation

Non-consecutive Residues
type: Class
subclass of: Experimental Information
comment: Indicates that two residues in a sequence are not consecutive and that there are a number of unsequenced residues between them.

Non standard residue
type: Class
subclass of: Modification
comment: Describes the occurrence of a non standard residue in the sequence record.

Non-terminal Residue
type: Class
subclass of: Experimental Information
comment: The residue at an extremity of the sequence is not the terminal residue.

NotObsolete
type: Class
equivalent class: Restriction
  on property: obsolete
  has value: false
disjoint with: Obsolete
comment: A class introduced to group all records that are currently in the database.
equivalent class: Restriction
  on property: obsolete
  has value: false

NotObsoleteProtein
type: Class
subclass of: NotObsolete
subclass of: Protein
subclass of: Restriction
  on property: sequence
  some values from: Simple Sequence
subclass of: Restriction
  on property: existence
  some values from: Protein Existence
subclass of: Restriction
  on property: organism
  cardinality: 1
subclass of: Restriction
  on property: sequence
  some values from: Simple Sequence
subclass of: Restriction
  on property: existence
  some values from: Protein Existence
subclass of: Restriction
  on property: organism
  cardinality: 1

NotObsoleteTaxon
type: Class
subclass of: NotObsolete
subclass of: Taxon
subclass of: Restriction
  on property: scientific name
  cardinality: 1
subclass of: Restriction
  on property: scientific name
  cardinality: 1

DNA Binding
type: Class
subclass of: Region
comment: Extent of a DNA-binding region.

Nucleotide Mapping Statement
type: Class
subclass of: Statement
comment: The relationship between a protein and a nucleotide sequence.

Nucleotide Resource
type: Class
equivalent class: Restriction
  on property: located on
  min cardinality: 1
subclass of: Resource
comment: A resource that descripes a nucleotide sequence.
equivalent class: Restriction
  on property: located on
  min cardinality: 1

Observation Citation
type: Class
subclass of: Unpublished Citation
comment: Citation of an unpublished result.

Obsolete
type: Class
equivalent class: Restriction
  on property: obsolete
  has value: true
comment: The class of all obsolete records in the database (i.e. records that where once published but are now removed).
equivalent class: Restriction
  on property: obsolete
  has value: true

ObsoleteTaxon
type: Class
subclass of: Obsolete
subclass of: Taxon
comment: Taxa are occasionally removed from the taxonomy database (particularly internal nodes, during a taxonomic revision) – these taxids are deleted, and are not reused.

Organelle
type: Class

Orientation
type: Class
subclass of: Subcellular Location

Other DNA
type: Class
subclass of: DNA

Other RNA
type: Class
subclass of: RNA

pH Dependence
type: Class
subclass of: Biophysicochemical Property
comment: Describes the optimum pH for enzyme activity and/or the variation of enzyme activity with pH variation.

PTM
type: Class
subclass of: Annotation
comment: Description of a posttranslational modification.

Part
type: Class
subclass of: Thing
comment: Description of a part of a protein.

Participant
type: Class
comment: A participant in a protein-protein interaction.

Patent Citation
type: Class
subclass of: Published Citation
comment: A patent application.

Pathway
type: Class
subclass of: Class
comment: A hierarchical discription of a metabolic pathway.

Pathway
type: Class
subclass of: Annotation
comment: Description of the metabolic pathways with which a protein is associated.

Peptide
type: Class
subclass of: Molecule Processing
comment: Extent of a released active peptide.

Pharmaceutical
type: Class
subclass of: Annotation
comment: Description of the use of a protein as a pharmaceutical drug.

Polymorphism
type: Class
subclass of: Annotation
comment: Description of polymorphisms.

Propeptide
type: Class
subclass of: Molecule Processing
comment: Extent of a propeptide.

Protein
type: Class
subclass of: Thing
subclass of: Restriction
  on property: replaces
  all values from: Protein
subclass of: Restriction
  on property: replaced by
  all values from: Protein
disjoint with: Sequence
comment: Description of a protein.
subclass of: Restriction
  on property: replaces
  all values from: Protein
subclass of: Restriction
  on property: replaced by
  all values from: Protein

Protein Family
type: Class
comment: Desription of a set of related proteins.

Published Citation
type: Class
subclass of: Citation
disjoint with: Unpublished Citation

RNA Editing
type: Class
subclass of: Annotation
comment: Description of any type of RNA editing that leads to one or more amino acid changes.

Range
type: Class
equivalent class: Class
  union of: Class
    intersection of: Restriction
      on property: begin
      qualified cardinality: 1
      on data range: int
    intersection of: Restriction
      on property: end
      max qualified cardinality: 1
      on data range: int
  union of: Class
    intersection of: Restriction
      on property: end
      qualified cardinality: 1
      on data range: int
    intersection of: Restriction
      on property: begin
      max qualified cardinality: 1
      on data range: int
comment: A range of amino acids on a protein sequence.
equivalent class: Class
  union of: Class
    intersection of: Restriction
      on property: begin
      qualified cardinality: 1
      on data range: int
    intersection of: Restriction
      on property: end
      max qualified cardinality: 1
      on data range: int
  union of: Class
    intersection of: Restriction
      on property: end
      qualified cardinality: 1
      on data range: int
    intersection of: Restriction
      on property: begin
      max qualified cardinality: 1
      on data range: int

Rank
type: Class
comment: A rank of a taxon.

Redox Potential
type: Class
subclass of: Biophysicochemical Property
comment: Reports the value of the standard (midpoint) oxido-reduction potential(s) for electron transport proteins.

Region
type: Class
subclass of: Sequence Annotation

Repeat
type: Class
subclass of: Region
comment: Extent of an internal sequence repetition.

Resource
type: Class
equivalent class: Restriction
  on property: database
  cardinality: 1
comment: A life science resource.
equivalent class: Restriction
  on property: database
  cardinality: 1

Ribosomal Frameshifting
type: Class
subclass of: Alternative Products

Secondary Structure
type: Class
subclass of: Sequence Annotation
comment: Describes the secondary structure of proteins whose tertiary structure is known experimentally.

Sequence
type: Class
comment: An amino acid sequence.

Sequence Annotation
type: Class
subclass of: Annotation
comment: Description of a special region or site in a protein sequence.

Sequence Caution
type: Class
subclass of: Sequence Annotation
comment: Warning about possible errors related to the protein sequence

Sequence Conflict
type: Class
subclass of: Experimental Information
comment: Different sources report differing sequences.

Unsure Residue
type: Class
subclass of: Experimental Information
comment: Used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.

Signal Peptide
type: Class
subclass of: Molecule Processing
comment: Extent of a signal sequence (prepeptide).

Similarity
type: Class
subclass of: Annotation
comment: Description of the similarities (sequence or structural) of a protein with other proteins.

Simple Sequence
type: Class
subclass of: Known Sequence

Site
type: Class
subclass of: Sequence Annotation
comment: Any interesting single amino-acid site on the sequence, that is not defined by another feature key. It can also apply to an amino acid bond which is represented by the positions of the two flanking amino acids.

Status
type: Class
comment: Indicator for the reliability of a piece of information.

Strain
type: Class
comment: A strain of a species.

Structure Determination
type: Class
subclass of: Method
comment: An experimental method for determining the 3D structure of a protein.

Structure Mapping Statement
type: Class
subclass of: Statement
comment: The relationship between a protein and a 3D structure.

Structure Resource
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: method
    all values from: Structure Determination
  intersection of: Restriction
    on property: method
    cardinality: 1
subclass of: Resource
comment: A resource that describes the 3D structure of a protein.
equivalent class: Class
  intersection of: Restriction
    on property: method
    all values from: Structure Determination
  intersection of: Restriction
    on property: method
    cardinality: 1

Structured Name
type: Class
comment: A resource that holds a set of the known names for this protein together.

Subcellular Location
type: Class
subclass of: Thing

Subcellular Location
type: Class
subclass of: Annotation
comment: Description of the subcellular location of the mature protein.

Submission Citation
type: Class
subclass of: Published Citation
subclass of: Restriction
  on property: submittedTo
  cardinality: 1
comment: Data that was submitted directly to a database.
subclass of: Restriction
  on property: submittedTo
  cardinality: 1

Subunit
type: Class
subclass of: Annotation
comment: Description of the quaternary structure of a protein.

Taxon
type: Class
subclass of: Class
subclass of: Restriction
  on property: mnemonic
  max cardinality: 1
subclass of: Restriction
  on property: replaces
  all values from: Taxon
comment: An element of a taxonomy for classifying life forms.
subclass of: Restriction
  on property: mnemonic
  max cardinality: 1
subclass of: Restriction
  on property: replaces
  all values from: Taxon

Temperature Dependence
type: Class
subclass of: Biophysicochemical Property
comment: Indicates the optimum temperature for enzyme activity and/or the variation of enzyme activity with temperature variation; the thermostability/thermolability of the enzyme is also mentioned when it is known.

Thesis Citation
type: Class
subclass of: Published Citation
subclass of: Restriction
  on property: institution
  cardinality: 1
comment: A Ph.D. thesis.
subclass of: Restriction
  on property: institution
  cardinality: 1

Tissue
type: Class
comment: A tissue such as lung or heart.

Tissue Specificity
type: Class
subclass of: Annotation
comment: Description of the tissue specificity of a protein.

Topological Domain
type: Class
subclass of: Region
comment: A topological domain.

Topology
type: Class
subclass of: Subcellular Location

Toxic Dose
type: Class
subclass of: Annotation
comment: Information on the LD(50). LD stands for "Lethal Dose". LD(50) is the amount of a toxin, given all at once, which causes the death of 50% (one half) of a group of test animals.

Transcribed RNA
type: Class
subclass of: RNA

Transcript Resource
type: Class
subclass of: Resource

Transit Peptide
type: Class
subclass of: Molecule Processing
comment: Extent of a transit peptide (mitochondrion, chloroplast, thylakoid, cyanelle or microbody).

Transmembrane
type: Class
subclass of: Region
comment: Extent of a transmembrane region.

Transposon
type: Class
comment: A transposon

Turn
type: Class
subclass of: Secondary Structure
comment: Turns within the experimentally determined protein structure.

Unassigned DNA
type: Class
subclass of: DNA

Unassigned RNA
type: Class
subclass of: RNA

Unknown Sequence
type: Class
subclass of: Sequence

Unpublished Citation
type: Class
subclass of: Citation

Viral cRNA
type: Class
subclass of: RNA
comment: Positive cRNA molecule that is made from from a single stranded genomic RNA.

Zinc Finger
type: Class
subclass of: Region
comment: Extent of a zinc finger region.

Atmospheric Pressure Ionization
type: Thing
type: Mass Measurement
comment: Mass measurement using Atmospheric Pressure Ionization

Apicoplast
type: Thing
type: Organelle

By Similarity
type: Thing
type: Status

Chloroplast
type: Thing
type: Organelle

Taxonomy rank Class
type: Thing
type: Rank

Cyanelle
type: Thing
type: Organelle

Electrospray Ionization
type: Thing
type: Mass Measurement

Electron Microscopy
type: Thing
type: Structure Determination
comment: The electron microscope is a microscope that can magnify very small details with high resolving power due to the use of electrons rather than light to scatter off material, magnifying at levels up to 500,000 times.

Evidence at protein level
type: Thing
type: Protein Existence

Evidence at transcript level
type: Protein Existence
type: Thing
comment: Indicates that the existence of a protein has not been strictly proven but that expression data (such as existence of cDNA(s), RT-PCR or Northern blots) indicate the existence of a transcript.

Indicates that there is some experimental evidence that the given annotation could apply.
type: Status
type: Thing

Fast Atom Bombardment
type: Thing
type: Mass Measurement

Taxonomy rank Family
type: Rank
type: Thing

Fiber Diffraction
type: Thing
type: Structure Determination

Taxonomy rank Forma
type: Thing
type: Rank

Taxonomy rank Genus
type: Rank
type: Thing

Hydrogenosome
type: Thing
type: Organelle

Inferred from homology
type: Thing
type: Protein Existence

Taxonomy rank Infraclass
type: Rank
type: Thing

Taxonomy rank Infraorder
type: Rank
type: Thing

Infrared Spectroscopy
type: Thing
type: Structure Determination
comment: A type of spectroscopy that uses the Infrared portion of the electromagnetic spectrum.

Taxonomy rank Kingdom
type: Rank
type: Thing

Liquid Secondary Ionization
type: Mass Measurement
type: Thing

Matrix-Assisted Laser Desorption
type: Mass Measurement
type: Thing

Mitochondion
type: Thing
type: Organelle

NMR Spectroscopy
type: Structure Determination
type: Thing

Neutron Diffraction
type: Thing
type: Structure Determination

Non-photosyntethic plastid
type: Thing
type: Organelle

Nuleomorph
type: Organelle
type: Thing

Taxonomy rank Order
type: Rank
type: Thing

Organellar chromatophore
type: Organelle
type: Thing

Plasma Desorption
type: Thing
type: Mass Measurement

Taxonomy rank Parvorder
type: Thing
type: Rank

Taxonomy rank Phylum
type: Rank
type: Thing

Plastid
type: Thing
type: Organelle

Potential
type: Thing
type: Status
comment: indicates that there is some logical or conclusive evidence that the given annotation could apply. This non-experimental qualifier is often used to present results from protein sequence analysis software tools, which are only annotated if the result makes sense in the biological context of a given protein. A typical example is the annotation of N-glycosylation sites in secreted proteins

Predicted
type: Thing
type: Protein Existence
comment: This is used for proteins without evidence at protein, transcript, or homology levels.

Prediction
type: Thing
type: Structure Determination

Probable
type: Status
type: Thing
comment: The status ‘Probable’ indicates stronger evidence than the qualifier ‘Potential’. This qualifier implies that there must be at least some experimental evidence, which indicates, that the information is expected to be found in the natural environment of a protein.

Surface Enhanced Laser Desorption Ionization
type: Thing
type: Mass Measurement

Taxonomic rank Species
type: Rank
type: Thing

Taxonomic rank Species Group
type: Thing
type: Rank

Taxonomic rank Species Subgroup
type: Rank
type: Thing

Taxonomic rank Subclass
type: Rank
type: Thing

Taxonomic rank Subfamily
type: Thing
type: Rank

Taxonomic rank Subgenus
type: Thing
type: Rank

Taxonomic rank Subkingdom
type: Rank
type: Thing

Taxonomic rank Suborder
type: Thing
type: Rank

Taxonomic rank Subphylum
type: Rank
type: Thing

Taxonomic rank Subspecies
type: Rank
type: Thing

Taxonomic rank Subtribe
type: Thing
type: Rank

Taxonomic rank Superclass
type: Thing
type: Rank

Taxonomic rank Superfamily
type: Thing
type: Rank

Taxonomic rank Superkingdom
type: Rank
type: Thing

Taxonomic rank Superorder
type: Thing
type: Rank

Taxonomic rank Superphylum
type: Thing
type: Rank

Taxonomic rank Tribe
type: Rank
type: Thing

Uncertain
type: Protein Existence
type: Thing

Taxonomic rank Varietas
type: Rank
type: Thing

X-Ray Crystallography
type: Structure Determination
type: Thing
comment: A technique in crystallography in which the pattern produced by the diffraction of x-rays through the closely spaced lattice of atoms in a crystal is recorded and then analyzed to reveal the nature of that lattice.